Article révisé par les pairs
| Résumé : | Recent experiments suggest that purified rat islet B-cells are devoid of high-affinity insulin receptors, but equipped with type 1 insulin-like growth factor (IGF-1) receptors. Therefore, the effect of IGF-1 upon insulin release by isolated rat islets was examined. IGF-1 (0.01 to 0.20 μg/ml) failed to affect insulin release evoked by D-glucose alone or by the association of the hexose and either dibutyryl-cyclic AMP or glucagon, even when enough guinea-pig anti-insulin serum was present in the incubation medium to bind all secreted insulin. These results suggest that IGF-1 may not play any major role in the immediate and direct regulation of insulin secretion. |
