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Downregulated bone morphogenetic protein signaling in nitrofen-induced congenital diaphragmatic hernia.

par Makanga, Martine ;Dewachter, Céline ;Maruyama, Hidekazu;Vuckovic, Aline ;Rondelet, Benoît ;Naeije, Robert ;Dewachter, Laurence
Référence Pediatric surgery international, 29, 8, page (823-834)
Publication Publié, 2013-08

Article révisé par les pairs

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Résumé :

Bone morphogenetic proteins (BMP) have been shown to play crucial roles in not only lung and heart development, but also in the pathogenesis of pulmonary vascular remodeling in pulmonary hypertension (PH). We therefore hypothesized that BMP signaling could be altered in nitrofen-induced congenital diaphragmatic hernia (CDH) and associated PH.