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Rat cardiac muscarinic receptors. II. Influence of thyroid status and cardiac hypertrophy.

par Robberecht, Patrick ;Waelbroeck, Magali ;Claeys, Magda;Nguyen Huu, Anh;Chatelain, Pierre ;Christophe, Jean
Référence Molecular pharmacology, 21, 3, page (589-593)
Publication Publié, 1982-05

Article révisé par les pairs

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Résumé :

The effects of the thyroid state and of aortic stenosis on muscarinic cholinergic binding sites in heart membranes were compared (with proper controls) by simultaneously determining total and high-affinity binding sites and estimating low-affinity binding sites by difference. Hyper- and hypothyroidism induced decreased and increased concentration of high-affinity agonist binding sites, respectively, supporting the hypothesis that these sites were directly regulated by thyroid hormones. This was not the case for low-affinity binding sites, as they decreased in number in both hyper- and hypothyroidism. In hyperthyroid rats, this decreased number of low-affinity binding sites could be due to the rapidly developing cardiac hypertrophy. Indeed, cardiac hypertrophy provoked by aortic stenosis led also to a decreased concentration of low-affinity binding sites without affecting the concentration of high-affinity binding sites.