Increased number of high-affinity muscarinic receptors in rat heart after phenylhydrazine treatment.

Chatelain, Pierre; Waelbroeck, Magali; De Neef, Philippe; Robberecht, Patrick; Christophe, Jean

doi:doi/10.1016/0014-2999(83)90478-8

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Increased number of high-affinity muscarinic receptors in rat heart after phenylhydrazine treatment.

par Chatelain, Pierre

Référence European journal of pharmacology, 91, 2-3, page (279-282)
Publication Publié, 1983-07

Article révisé par les pairs

Résumé :

The effect of phenylhydrazine-induced heart hypertrophy on muscarinic cholinergic binding sites was studied in heart membranes by determining total (with [3H]NMS) and high-affinity (with [3H]Oxo-M) binding sites and estimating low-affinity binding sites by difference. Phenylhydrazine induced an increased concentration of high-affinity binding sites without affecting the concentration of low-affinity binding sites. The KD values for the ligands were unaffected.

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