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Hyperuricemia and renal handling of urate in primary hyperparathyroidism.

par Pepersack, Thierry ;Jabbour, Nakhoul ;Fuss, Michel ;Karmali, Rafik ;Van Geertruyden, Jean ;Corvilain, Jacques
Référence Nephron, 53, 4, page (349-352)
Publication Publié, 1989

Article révisé par les pairs

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Résumé :

Serum urate and the renal handling of urate were measured in 37 patients with primary hyperparathyroidism and in normal sex- and age-matched subjects. Serum urate was increased in the hyperparathyroid group compared to the control group (6.23 +/- 1.46 versus 4.64 +/- 1.24 mg/100 ml; p less than 0.005), whereas the fractional excretion of urate was decreased in hyperparathyroid patients compared to the controls (6.80 +/- 2.69 versus 8.73 +/- 3.47%; p less than 0.005). Twenty-four of these hyperparathyroid patients were studied 6 months after surgical correction of their disease. Serum urate decreased after surgery (5.14 +/- 1.65 mg/100 ml) compared to the preoperative state (5.92 +/- 1.46 mg/100 ml) and was no longer different from the normal values. The possible mechanisms of hyperuricemia associated with the hyperparathyroid state are discussed.