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Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis.

par Allagnat, Florent ;Christulia, Foteini ;Ortis, Fernanda ;Pirot, Pierre ;Lortz, Stephan;Lenzen, Sigurd;Eizirik, Decio L. ;Cardozo, Alessandra K
Référence Diabetologia, 53, 6, page (1120-1130)
Publication Publié, 2010

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Titre:	Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis.
Auteur:	Allagnat, Florent; Christulia, Foteini; Ortis, Fernanda; Pirot, Pierre; Lortz, Stephan; Lenzen, Sigurd; Eizirik, Decio L.; Cardozo, Alessandra K
Informations sur la publication:	Diabetologia, 53, 6, page (1120-1130)
Statut de publication:	Publié, 2010
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Analysis of Variance
	Animals
	Apoptosis -- drug effects -- physiology
	Blotting, Western
	Cell Count
	Cell Survival -- drug effects
	Cells, Cultured
	DNA-Binding Proteins -- genetics -- metabolism
	Endoplasmic Reticulum -- drug effects -- genetics -- metabolism
	Fluorescent Antibody Technique
	Homeodomain Proteins -- genetics -- metabolism
	Indoles -- pharmacology
	Insulin -- genetics -- metabolism -- secretion
	Insulin-Secreting Cells -- cytology -- drug effects -- metabolism
	Interferon-gamma -- pharmacology
	Interleukin-8 -- pharmacology
	Maf Transcription Factors -- genetics -- metabolism
	Male
	RNA Interference
	RNA, Small Interfering
	Rats
	Rats, Wistar
	Reverse Transcriptase Polymerase Chain Reaction
	Trans-Activators -- genetics -- metabolism
	Transcription Factors -- genetics -- metabolism
	Transfection
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0012-186X
	info:doi/10.1007/s00125-010-1699-7
	info:scp/77952093535
	info:pmid/20349222