Association between SPARC mRNA expression, prognosis and response to neoadjuvant chemotherapy in early breast cancer: a pooled in-silico analysis.

Abdel Azim, Hatem Hamdy; Singhal, Sandeep; Ignatiadis, Michail; Desmedt, Christine; Fumagalli, Debora; Veys, Isabelle; Larsimont, Denis; Piccart-Gebhart, Martine; Michiels, Stefan; Sotiriou, Christos

doi:doi/10.1371/journal.pone.0062451

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Association between SPARC mRNA expression, prognosis and response to neoadjuvant chemotherapy in early breast cancer: a pooled in-silico analysis.

par Abdel Azim, Hatem Hamdy

;Piccart-Gebhart, Martine

;Michiels, Stefan

;Sotiriou, Christos

Référence PloS one, 8, 4, page (e62451)
Publication Publié, 2013-04

Article révisé par les pairs

Résumé :

SPARC is an important regulator of the extracellular matrix and has been suggested to improve delivery of albumin-bound cytotoxics. However, little is known regarding its role in breast cancer (BC).

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