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Association between SPARC mRNA expression, prognosis and response to neoadjuvant chemotherapy in early breast cancer: a pooled in-silico analysis.

par Abdel Azim, Hatem Hamdy ;Singhal, Sandeep ;Ignatiadis, Michail ;Desmedt, Christine ;Fumagalli, Debora ;Veys, Isabelle ;Larsimont, Denis ;Piccart-Gebhart, Martine ;Michiels, Stefan ;Sotiriou, Christos
Référence PloS one, 8, 4, page (e62451)
Publication Publié, 2013-04

Article révisé par les pairs

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Résumé :

SPARC is an important regulator of the extracellular matrix and has been suggested to improve delivery of albumin-bound cytotoxics. However, little is known regarding its role in breast cancer (BC).