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Segmental determination in Drosophila central nervous system: analysis of the abdominal-A region of the bithorax complex.

par Jijakli, Hassan ;Ghysen, Alain
Référence The International journal of developmental biology, 36, 1, page (93-99)
Publication Publié, 1992-03

Article révisé par les pairs

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Résumé :

The bithorax complex (BX-C) comprises several genes required for the diversification of posterior segments in Drosophila. The BX-C genes control segment differences not only in the epidermis but in other tissues as well, especially in the central nervous system. We have examined the control of one segment-specific neural structure: the lateral dots, a paired structure present in the first abdominal segment of the larval CNS and absent in all following abdominal segments. Our results show that the suppression of lateral dots in segments A3 and A4 requires the presence of two active copies of one of the BX-C genes, abdominal-A (abd-A). We also show that the adjacent BX-C regions, iab-3 and iab-4, can act in trans on abd-A not only when the two copies of BX-C are paired but also, at least to some extent, when pairing is disturbed.