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Purinergic P2Y₂ receptors promote neutrophil infiltration and hepatocyte death in mice with acute liver injury.

par Ayata, Cemil Korcan;Ganal, Stephanie C;Hockenjos, Birgit;Willim, Karolina;Vieira, Rodolfo Paula;Grimm, Melanie;Robaye, Bernard ;Boeynaems, Jean-Marie ;Di Virgilio, Francesco;Pellegatti, Patrizia;Diefenbach, Andreas;Idzko, Marco;Hasselblatt, Peter
Référence Gastroenterology, 143, 6, page (1620-1629.e4)
Publication Publié, 2012-12

Article révisé par les pairs

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Résumé :

During progression of liver disease, inflammation affects survival of hepatocytes. Endogenous release of adenosine triphosphate (ATP) in the liver activates purinergic P2 receptors (P2R), which regulate inflammatory responses, but little is known about the roles of these processes in the development of acute hepatitis.