EORTC 24051: unexpected side effects in a phase I study of TPF induction chemotherapy followed by chemoradiation with lapatinib, a dual EGFR/ErbB2 inhibitor, in patients with locally advanced resectable larynx and hypopharynx squamous cell carcinoma.

Lalami, Yassine; Specenier, Pol M; Awada, Ahmad; Lacombe, Denis; Liberatoscioli, Cecilia; Fortpied, Catherine; El-Hariry, Iman; Bogaerts, Jan; Andry, Guy; Langendijk, Johannes A; Vermorken, Jan B

doi:doi/10.1016/j.radonc.2012.08.006

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EORTC 24051: unexpected side effects in a phase I study of TPF induction chemotherapy followed by chemoradiation with lapatinib, a dual EGFR/ErbB2 inhibitor, in patients with locally advanced resectable larynx and hypopharynx squamous cell carcinoma.

par Lalami, Yassine

;Specenier, Pol M ;Awada, Ahmad

;Lacombe, Denis ;Liberatoscioli, Cecilia ;Fortpied, Catherine ;El-Hariry, Iman ;Bogaerts, Jan ;Andry, Guy

;Langendijk, Johannes A ;Vermorken, Jan B
Référence Radiotherapy and oncology, 105, 2, page (238-240)
Publication Publié, 2012-11

Article révisé par les pairs

Résumé :

In this phase I/II study, the addition of lapatinib (LAP) was investigated in combination with the sequential use of both approaches TPF induction chemotherapy (ICT) followed by chemoradiation (CRT) in locally advanced larynx or hypopharynx squamous cell carcinoma.

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