par Thomas, René 
Référence Journal of Molecular Biology, 8, 2, page (247–253)
Publication Publié, 1964
Référence Journal of Molecular Biology, 8, 2, page (247–253)
Publication Publié, 1964
Article révisé par les pairs
| Résumé : | A procedure with a high resolving power has been devised in order to test the linkage between the receptor (“operator”) and emittor (regulator gene) genetic factors responsible for immunity in temperate bacteriophages. In a cross between phages λ and 434 hybrid the frequency of viable particles recombined between the operator and regulator gene (if any) is less than 4 × 10−6. In the absence of complicating factors (such as a lack of pairing between the immunity regions of λ and 434) this would mean that the two structures responsible for the specificity of immunity, if distinct, are adjacent to each other and that very few, if any, nucleotide pairs in this border region are interchangeable between λ and 434 hybrid without loss of function. Whatever its structural basis (close vicinity, lack of pairing, etc.), the absence of such recombinations may have an evolutionary significance since it is a condition for the maintenance of the temperate character. © 1964, Academic Press Inc. (London) Ltd.. All rights reserved. |
