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Phase I trial to investigate the safety, pharmacokinetics and efficacy of sorafenib combined with docetaxel in patients with advanced refractory solid tumours.

par Awada, Ahmad ;Hendlisz, Alain ;Christensen, O;Lathia, Chetan;Bartholomeus, Sylvie;Lebrun, Fabienne;de Valeriola, Dominique ;Brendel, Erich;Radtke, M.;Delaunoit, Thierry ;Piccart-Gebhart, Martine ;Gil, Thierry
Référence European journal of cancer, 48, 4, page (465-474)
Publication Publié, 2012-03

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Titre:	Phase I trial to investigate the safety, pharmacokinetics and efficacy of sorafenib combined with docetaxel in patients with advanced refractory solid tumours.
Auteur:	Awada, Ahmad; Hendlisz, Alain; Christensen, O; Lathia, Chetan; Bartholomeus, Sylvie; Lebrun, Fabienne; de Valeriola, Dominique; Brendel, Erich; Radtke, M.; Delaunoit, Thierry; Piccart-Gebhart, Martine; Gil, Thierry
Informations sur la publication:	European journal of cancer, 48, 4, page (465-474)
Statut de publication:	Publié, 2012-03
Sujet CREF:	Cancérologie
Mots-clés:	Combination
	Docetaxel
	Phase I
	Solid tumours
	Sorafenib
MeSH keywords:	Adult
	Aged
	Antineoplastic Combined Chemotherapy Protocols -- administration & dosage -- adverse effects -- pharmacokinetics -- therapeutic use
	Benzenesulfonates -- administration & dosage -- adverse effects -- pharmacokinetics
	Cohort Studies
	Disease Progression
	Drug Administration Schedule
	Drug Resistance, Neoplasm -- drug effects
	Female
	Humans
	Male
	Middle Aged
	Neoplasms -- drug therapy -- pathology
	Pyridines -- administration & dosage -- adverse effects -- pharmacokinetics
	Taxoids -- administration & dosage -- adverse effects -- pharmacokinetics
	Treatment Outcome
Note générale:	Clinical Trial, Phase I
	Journal Article
	Research Support, Non-U.S. Gov't
	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0959-8049
	info:doi/10.1016/j.ejca.2011.12.026
	info:pii/S0959-8049(11)01075-6
	info:scp/84857062069
	info:pmid/22285181