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Dual human epidermal growth factor receptor 2 blockade: another step forward in treating patients with human epidermal growth factor receptor 2-positive breast cancer.

par Zardavas, Dimitros ;Bozovic, Ivana ;de Azambuja, Evandro
Référence Current opinion in oncology, 24, 6, page (612-622)
Publication Publié, 2012-11

Article révisé par les pairs

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Résumé :

Many antihuman epidermal growth factor receptor (anti-HER2)-targeted agents, covering a broad spectrum of mechanisms of action, have been recently developed. The concept of dual anti-HER2 blockade has been preclinically and clinically assessed with positive results. In this article, the authors review the biologic rationale for dual HER2 blockade, along with the clinical findings.