Titre:
  • A phase II trial to assess efficacy and safety of afatinib in extensively pretreated patients with HER2-negative metastatic breast cancer.
Auteur:Schuler, M; Awada, Ahmad; Harter, Philipp; Canon, Jean-Luc; Possinger, Kurt; Schmidt, M; De Greve, Jacques; Neven, Patrick; Dirix, Luc Y; Jonat, Walter; Beckmann, Matthias W; Schütte, Jochen; Fasching, Peter A; Gottschalk, Nina; Besse-Hammer, Tatiana; Fleischer, Frank; Wind, Sven; Uttenreuther-Fischer, Martina; Piccart-Gebhart, Martine; Harbeck, Nadia
Informations sur la publication:Breast cancer research and treatment, 134, 3, page (1149-1159)
Statut de publication:Publié, 2012-08
Sujet CREF:Cancérologie
Mots-clés:Afatinib
EGFR TKI
HER2-negative breast cancer
Metastatic breast cancer
Triple-negative breast cancer
MeSH keywords:Adult
Aged
Aged, 80 and over
Antineoplastic Agents -- adverse effects -- pharmacology -- therapeutic use
Breast Neoplasms -- drug therapy -- metabolism -- mortality -- pathology
Cohort Studies
Female
Humans
Middle Aged
Neoplasm Metastasis
Protein Kinase Inhibitors -- adverse effects -- pharmacology -- therapeutic use
Quinazolines -- administration & dosage -- adverse effects -- therapeutic use
Receptor, erbB-2 -- deficiency -- metabolism
Survival Analysis
Treatment Outcome
Tumor Markers, Biological -- metabolism
Note générale:Clinical Trial, Phase II
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue:Anglais
Identificateurs:urn:issn:0167-6806
info:doi/10.1007/s10549-012-2126-1
info:scp/84868191989
info:pmid/22763464
PMC3409367