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Seasonality in clinical onset of type 1 diabetes in belgian patients above the age of 10 is restricted to HLA-DQ2/DQ8-negative males, which explains the male to female excess in incidence.

par Weets, Ilse;Kaufman, L.;Van Der Auwera, Bart;Crenier, Laurent ;Rooman, R P A;De Block, Christophe;casteels, Kristina;Weber, E.;Coeckelberghs, M;Laron, Z;Pipeleers, Daniel;Gorus, F K;Belgian Diabetes Registry,
Référence Diabetologia, 47, 4, page (614-621)
Publication Publié, 2004-04

Article révisé par les pairs

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Résumé :

Type 1 diabetes arises from an interplay between environmental and genetic factors. The reported seasonality at diagnosis supports the hypothesis that currently unknown external triggers play a role in the onset of the disease. We investigated whether a seasonal pattern is observed at diagnosis in Belgian Type 1 diabetic patients, and if so whether seasonality varies according to age, sex and genetic risk, all known to affect the incidence of Type 1 diabetes.