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Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock.

par He, Xinrong ;Su, FUHONG ;Velissaris, Dimitrios;Salgado, Diamantino ;de Souza Barros, Dalton;Lorent, Sophie ;Taccone, Fabio ;Vincent, Jean Louis ;De Backer, Daniel
Référence Critical care medicine, 40, 10, page (2833-2840)
Publication Publié, 2012-10

Article révisé par les pairs

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Résumé :

Supplementation with tetrahydrobiopterin, a nitric oxide synthase cofactor, may reduce microvascular endothelial dysfunction in severe sepsis. We studied whether tetrahydrobiopterin administration exerts beneficial effects in an ovine septic shock model.