Titre:
  • A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis.
Auteur:Rice, Todd W; Wheeler, Arthur; Bernard, Gordon; Vincent, Jean Louis; Angus, Derek; Aikawa, Naoki; Demeyer, Ignace; Sainati, Stephen; Amlot, Nicholas; Cao, Charlie; Ii, Masayuki; Matsuda, Hideyasu; Mouri, Kouji; Cohen, Jonathan
Informations sur la publication:Critical care medicine, 38, 8, page (1685-1694)
Statut de publication:Publié, 2010-08
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:cytokines
interleukin-6
mortality
severe sepsis
TAK-242
Toll-like receptor-4
Toll-like receptors
MeSH keywords:Adult
Aged
Cytokines -- drug effects -- metabolism
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Female
Follow-Up Studies
Hospital Mortality -- trends
Humans
Infusions, Intravenous
Male
Middle Aged
Multiple Organ Failure -- prevention & control
Probability
Pulse Therapy, Drug
Reference Values
Risk Assessment
Sepsis -- diagnosis -- drug therapy -- mortality
Sulfonamides -- administration & dosage -- adverse effects
Survival Analysis
Treatment Outcome
Note générale:Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
Langue:Anglais
Identificateurs:urn:issn:0090-3493
info:doi/10.1097/CCM.0b013e3181e7c5c9
info:pii/S0090349310604130
info:scp/77954953617
info:pmid/20562702