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Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter.

par Guignabert, Christophe;Tu, Ly;Izikki, Mohamed;Dewachter, Laurence ;Zadigue, Patricia;Humbert, Marc;Adnot, Serge;Fadel, Elie;Eddahibi, Saadia
Référence The FASEB journal, 23, 12, page (4135-4147)
Publication Publié, 2009-12

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Titre:	Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter.
Auteur:	Guignabert, Christophe; Tu, Ly; Izikki, Mohamed; Dewachter, Laurence; Zadigue, Patricia; Humbert, Marc; Adnot, Serge; Fadel, Elie; Eddahibi, Saadia
Informations sur la publication:	The FASEB journal, 23, 12, page (4135-4147)
Statut de publication:	Publié, 2009-12
Sujet CREF:	Physiologie générale [biophysique]
MeSH keywords:	Animals
	Apoptosis -- drug effects
	Cell Proliferation -- drug effects
	Cells, Cultured
	Dichloroacetic Acid -- therapeutic use
	Female
	Fluoxetine -- pharmacology
	Gene Expression Regulation -- physiology
	Hypertension, Pulmonary -- drug therapy
	Kv1.5 Potassium Channel -- genetics -- metabolism
	Male
	Mice
	Microfilament Proteins -- genetics -- metabolism
	Muscle Proteins -- genetics -- metabolism
	Muscle, Smooth, Vascular -- cytology
	Myocytes, Smooth Muscle -- drug effects -- metabolism
	NFATC Transcription Factors -- genetics -- metabolism
	Pulmonary Artery
	Serotonin Plasma Membrane Transport Proteins -- genetics -- metabolism
	Serotonin Uptake Inhibitors -- pharmacology
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0892-6638
	info:doi/10.1096/fj.09-131664
	info:pii/fj.09-131664
	info:pmid/19679640