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Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.

par Tanioka, Toshihiro;Tamura, Yoshiaki;Fukaya, Makiko ;Shinozaki, Shohei;Mao, Ji;Kim, Minhye;Shimizu, Nobuyuki;Kitamura, Tadahiro;Kaneki, Masao
Référence The Journal of biological chemistry, 286, 33, page (29388-29396)
Publication Publié, 2011-08

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Titre:	Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.
Auteur:	Tanioka, Toshihiro; Tamura, Yoshiaki; Fukaya, Makiko; Shinozaki, Shohei; Mao, Ji; Kim, Minhye; Shimizu, Nobuyuki; Kitamura, Tadahiro; Kaneki, Masao
Informations sur la publication:	The Journal of biological chemistry, 286, 33, page (29388-29396)
Statut de publication:	Publié, 2011-08
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Acetylcysteine -- analogs & derivatives -- pharmacology
	Animals
	Anthracenes -- pharmacology
	Cell Line, Tumor
	Cysteine Proteinase Inhibitors -- pharmacology
	Enzyme Activation -- drug effects -- physiology
	Gene Expression Regulation -- drug effects -- physiology
	Glycogen Synthase Kinase 3 -- antagonists & inhibitors -- genetics -- metabolism
	Humans
	Insulin Receptor Substrate Proteins -- biosynthesis -- genetics
	Insulin-Secreting Cells -- cytology -- metabolism
	Interferon-gamma -- genetics -- metabolism
	Interleukin-1beta -- genetics -- metabolism
	JNK Mitogen-Activated Protein Kinases -- antagonists & inhibitors -- genetics -- metabolism
	Leupeptins -- pharmacology
	Mice
	Nitric Oxide Donors -- pharmacology
	Nitric Oxide Synthase Type II -- genetics -- metabolism
	Proteasome Endopeptidase Complex -- genetics -- metabolism
	Proteasome Inhibitors
	Rats
Note générale:	Journal Article
	Research Support, N.I.H., Extramural
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0021-9258
	info:doi/10.1074/jbc.M110.192732
	info:pii/M110.192732
	info:pmid/21700708
	PMC3190744