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Robust non-linear differential equation models of gene expression evolution across Drosophila development.

par Haye, Alexandre ;Albert, Jaroslav ;Rooman, Marianne
Référence BMC research notes, 5, page (46)
Publication Publié, 2012

Article révisé par les pairs

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Résumé :

This paper lies in the context of modeling the evolution of gene expression away from stationary states, for example in systems subject to external perturbations or during the development of an organism. We base our analysis on experimental data and proceed in a top-down approach, where we start from data on a system's transcriptome, and deduce rules and models from it without a priori knowledge. We focus here on a publicly available DNA microarray time series, representing the transcriptome of Drosophila across evolution from the embryonic to the adult stage.