par Vergote, Thomas;Nahra, Fady;Welle, Alexandre;Luhmer, Michel ;Wouters, Johan ;Mager, Nathalie;Riant, Olivier;Leyssens, Tom
Référence Chemistry, 18, 3, page (793-798)
Publication Publié, 2012-01
Référence Chemistry, 18, 3, page (793-798)
Publication Publié, 2012-01
Article révisé par les pairs
Résumé : | To be or not to bifluoride: Two synthetic pathways to unprecedented N-heterocyclic carbene copper(I) bifluoride complexes have been developed. Catalytic tests demonstrated that copper(I) bifluorides are very efficient catalysts, which do not require any additional activating agent. The first Cu-catalyzed diastereoselective allylation of (R)-N-tert-butanesulfinyl aldimines was also established. The method enables efficient, simple and general synthesis of enantiomerically enriched homoallylic amines at room temperature in high yields. |