Deoxythymidine and deoxycytidine incorporation into DNA in B leukemic cells

Vertongen, Françoise; Lebacq, Anne Marie; Fondu, Pierre; Mandelbaum, Israel

doi:doi/10.1002/ajh.2830210312

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Deoxythymidine and deoxycytidine incorporation into DNA in B leukemic cells

par Vertongen, Françoise

;Lebacq, Anne Marie ;Fondu, Pierre

;Mandelbaum, Israel

Référence American journal of hematology, 21, 3, page (323-326)
Publication Publié, 1986-03

Article révisé par les pairs

Résumé :

Measurements of radioactive DNA after incubation of normal and B leukemic peripheral mononuclear cells, from c-ALL and CLL with labeled deoxythymidine (dTh) and deoxycytidine (dCt) showed that for dTh, incorporation into DNA was similar for normal and c-ALL cells but lower in B-CLL cells and that for dCt, incorporation was highest in c-ALL and lowest in CLL cells. These results contrast with those of dTh and dCt kinase activities; the former has been previously found elevated in c-ALL cells, and the latter is found, in the present study, similar in the three groups tested.

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