par Le Buanec, Hélène 
;Paturance, Sébastien;Couillin, Isabelle;Schnyder-Candrian, Silvia;Larcier, Patrick;Ryffel, Bernard;Bizzini, Bernard;Bensussan, Armand;Burny, Arsène ;Gallo, Robert C.;Zagury, Daniel;Peltre, Gabriel
Référence Vaccine, 25, 41, page (7206-7216)
Publication Publié, 2007-10
;Paturance, Sébastien;Couillin, Isabelle;Schnyder-Candrian, Silvia;Larcier, Patrick;Ryffel, Bernard;Bizzini, Bernard;Bensussan, Armand;Burny, Arsène ;Gallo, Robert C.;Zagury, Daniel;Peltre, GabrielRéférence Vaccine, 25, 41, page (7206-7216)
Publication Publié, 2007-10
Article révisé par les pairs
| Résumé : | Pathogenesis of allergic inflammatory disorders is characterized by allergen-induced IgE stimulated by Th2 cytokines including mainly IL-4 overproduction. To counteract IL-4 effects in sensitized-BALB/c mice, we prepared an IL-4 derivative immunogen, made of KLH and murine IL-4 heterocomplex, termed mIL-4 kinoid. Murine IL-4 kinoid immunized mice produced high titer of anti-IL-4 neutralizing Abs. In contrast to KLH control immunization kinoid immunization reversed the allergic IgE:IgG ratio hallmark in rBet v 1a sensitized mice and reduced pulmonary eosinophil recruitment and bronchial hyperreactivity in Ova-sensitized mice. These data pave the way to alternative therapies to combat allergic conditions. © 2007 Elsevier Ltd. All rights reserved. |
