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Effects of CGRP on human osteoclast-like cell formation: A possible connection with the bone loss in neurological disorders?

par Akopian, Aram;Demulder, Anne ;Ouriaghli, Frank;Corazza, Francis ;Fondu, Pierre ;Bergmann, Pierre
Référence Peptides, 21, 4, page (559-564)
Publication Publié, 2000-04

Article révisé par les pairs

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Résumé :

Osteoclast-like cell (OCL-like) differentiation is increased in long term cultures of bone marrow taken from paralyzed areas of paraplegic patients. Among the neuropeptides recently described in bone, calcitonin gene-related peptide (CGRP) has been shown in animal studies to inhibit bone resorption in vivo and OCL-like differentiation in vitro: its deficiency could thus be a link between the neural lesion and increased OCL-like production in paraplegia and some other neurologic disorders. We therefore investigated in this study the effects of CGRP on human OCL-like formation and found that it indeed has an inhibitory effect mediated at least in part via cAMP. Copyright (C) 2000 Elsevier Science Inc.