Article révisé par les pairs
| Résumé : | Corticosteroids can restore vascular permeability in experimental cerebral oedema, reduce the release of free radicals and inhibit lipid peroxidation of cellular membranes. Experimental studies have shown beneficial results of corticosteroids in traumatic injuries of the central nervous system. Systematic reviews of randomised trials have recommended that corticosteroids should not be administered in head injury (high degree of certitude, standard). Nevertheless, a potential reduction of the risk for death or disability of 2% has justified performing a large randomised multicentre trial in order to confirm or refute this hypothesis. This study is in progress. In acute spinal cord injury, methylprednisolone (30 mg/kg in 1 h followed by 5.4 mg/kg per h) could be used during 24 h for trauma within 3 h, or during 48 h for trauma after 3 h and within 8 h time window. Methylprednisolone is not recommended for spinal cord trauma after 8 h. © 2004 Société de réanimation de langue française. Publié par Elsevier SAS. Tous droits réservés. |
