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MLN8054, a small molecule inhibitor of aurora kinase a, sensitizes androgen-resistant prostate cancer to radiation.

par Moretti, Luigi ;Niermann, Kenneth;Schleicher, Stephen;Giacalone, Nicholas J;Varki, Vinod;Kim, Kwang Woon;Kopsombut, Prapaporn;Jung, Dae Kwang;Lu, Bo
Référence International journal of radiation oncology, biology, physics, 80, 4, page (1189-1197)
Publication Publié, 2011-07

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Titre:	MLN8054, a small molecule inhibitor of aurora kinase a, sensitizes androgen-resistant prostate cancer to radiation.
Auteur:	Moretti, Luigi; Niermann, Kenneth; Schleicher, Stephen; Giacalone, Nicholas J; Varki, Vinod; Kim, Kwang Woon; Kopsombut, Prapaporn; Jung, Dae Kwang; Lu, Bo
Informations sur la publication:	International journal of radiation oncology, biology, physics, 80, 4, page (1189-1197)
Statut de publication:	Publié, 2011-07
Sujet CREF:	Cancérologie
Mots-clés:	Aurora kinase A
	MLN8054
	Prostate cancer
	Radiation
MeSH keywords:	Androgens -- therapeutic use
	Animals
	Apoptosis -- radiation effects
	Benzazepines -- therapeutic use
	Caspase 3 -- analysis
	Cell Cycle
	Cell Line, Tumor
	Cell Survival -- drug effects -- radiation effects
	DNA Breaks, Double-Stranded
	Drug Resistance, Neoplasm -- drug effects
	Histones -- analysis
	Humans
	Immunoblotting -- methods
	Ki-67 Antigen -- analysis
	Male
	Mice
	Mice, Nude
	Nocodazole -- therapeutic use
	Prostatic Neoplasms -- drug therapy -- pathology -- radiotherapy
	Protein-Serine-Threonine Kinases -- antagonists & inhibitors
	Radiation Tolerance -- drug effects
	Radiation-Sensitizing Agents -- therapeutic use
Note générale:	Journal Article
	Research Support, U.S. Gov't, Non-P.H.S.
	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0360-3016
	info:doi/10.1016/j.ijrobp.2011.01.060
	info:pii/S0360-3016(11)00235-5
	info:scp/79959355129
	info:pmid/21514073