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Origin and significance of the heterogeneity of protein hormones

par Nagy, Anne-Marie ;Meuris, Sylvain ;Robyn, Claude
Référence Nuclear medicine and biology, 21, 3, page (317-330)
Publication Publié, 1994

Article révisé par les pairs

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Résumé :

The heterogeneity of circulating protein hormone is the result of multiple steps including gene expression, mRNA maturation, post-translational processing and peripheral catabolism. As a consequence of these cumulative events, its seems difficult to evaluate the endocrine function by using specific radioimmunoassays for each circulating variant of a protein hormone. Moreover, the discovery of new molecular variants of protein hormones with unknown biological significance complicates the standardization and the clinical interpretation of immunoassays.