Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomised controlled trial.

Gianni, Luca; Dafni, Urania; Gelber, Richard; de Azambuja, Evandro; Muehlbauer, Susanne; Goldhirsch, Aron; Untch, Michael; Smith, Ian; Baselga, José; Jackisch, Christian; Cameron, David A; Mano, Max S.; Pedrini, José Luiz; Veronesi, Andrea; Mendiola, Cesar; Pluzanska, Anna; Semiglazov, Vladimir; Vrdoljak, Eduard; Eckart, Michael J; Shen, Zhenzhou; Skiadopoulos, George; Procter, Marion; Pritchard, Kathleen; Piccart-Gebhart, Martine; Bell, Richard H; Herceptin Adjuvant (HERA) Trial Study Team

doi:doi/10.1016/S1470-2045(11)70033-X

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Résumé :

Treatment with adjuvant trastuzumab for 1 year improves disease-free survival and overall survival in patients with human epidermal growth factor receptor 2 (HER2)-positive early breast cancer. We aimed to assess disease-free survival and overall survival after a median follow-up of 4 years for patients enrolled on the Herceptin Adjuvant (HERA) trial.

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