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Safety and pharmacokinetics of sorafenib combined with capecitabine in patients with advanced solid tumors: results of a phase 1 trial.

par Awada, Ahmad ;Gil, Thierry ;Whenham, Nicolas;Van Hamme, Julie;Besse-Hammer, Tatiana;Brendel, Erich;Delesen, Heinz;Joosten, Miranda C;Lathia, Chetan;Loembé, Bienvenu A;Piccart-Gebhart, Martine ;Hendlisz, Alain
Référence Journal of clinical pharmacology, 51, 12, page (1674-1684)
Publication Publié, 2011-12

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Titre:	Safety and pharmacokinetics of sorafenib combined with capecitabine in patients with advanced solid tumors: results of a phase 1 trial.
Auteur:	Awada, Ahmad; Gil, Thierry; Whenham, Nicolas; Van Hamme, Julie; Besse-Hammer, Tatiana; Brendel, Erich; Delesen, Heinz; Joosten, Miranda C; Lathia, Chetan; Loembé, Bienvenu A; Piccart-Gebhart, Martine; Hendlisz, Alain
Informations sur la publication:	Journal of clinical pharmacology, 51, 12, page (1674-1684)
Statut de publication:	Publié, 2011-12
Sujet CREF:	Cancérologie
MeSH keywords:	Adult
	Aged
	Antineoplastic Agents -- administration & dosage
	Antineoplastic Combined Chemotherapy Protocols -- adverse effects -- blood -- pharmacokinetics
	Area Under Curve
	Benzenesulfonates -- administration & dosage
	Colonic Neoplasms -- drug therapy -- metabolism
	Deoxycytidine -- administration & dosage -- analogs & derivatives
	Diarrhea -- chemically induced
	Fatigue -- chemically induced
	Female
	Fluorouracil -- administration & dosage -- analogs & derivatives
	Hand-Foot Syndrome -- etiology
	Humans
	Male
	Middle Aged
	Neoplasms -- drug therapy -- metabolism
	Protein Kinase Inhibitors -- administration & dosage
	Pyridines -- administration & dosage
Note générale:	Clinical Trial, Phase I
	Journal Article
	Research Support, Non-U.S. Gov't
	FLWIN
	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0091-2700
	info:doi/10.1177/0091270010386226
	info:pii/0091270010386226
	info:scp/80051564889
	info:pmid/21209247