Résumé : As regions around the world are considering increased integration of key energy, transport or other infrastructure networks, issues build in the design of the supranational national regulation needed in that context are increasingly well recognized. Solutions are however slow to emerge. This paper reviews the challenges and discusses the directions suggested by theory to address these challenges. It highlight the potentially counterproductive effects of common standard policy recommendations discussed at the political level. The paper also identifies key research areas as the review of match between theory and evidence suggest that we still have to address significant gaps in our collective understanding of the impediments to desirable integration efforts.