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Assessment of the clinical and virological protection provided by a commercial inactivated bovine viral diarrhoea virus genotype 1 vaccine against a BVDV genotype 2 challenge.

par Hamers, Claude;Couvreur, Bernard ;Dehan, Pierre ;Letellier, Carine;Fischer, L;Brun, Annick;Lewalle, Philippe ;Michaux, Catherine;Pastoret, Paul-Pierre;Kerkhofs, Pierre
Référence Veterinary record, 153, 8, page (236-240)
Publication Publié, 2003-08

Article révisé par les pairs

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Résumé :

A new genotype of bovine viral diarrhoea virus (BVDV), designated BVDV-2, has emerged in the last decade and in recent years the prevalence of BVDV-2 strains has increased. A vaccination-challenge study was carried out to determine the cross-protective efficacy of a commercial inactivated vaccine containing a BVDV-1 strain. A group of five BVDV-free calves was vaccinated twice and a second group of five calves served as negative controls. Two months after the first vaccination, all the calves were challenged intranasally with BVDV-2 strain BVD890. The clinical signs of disease, the changes in haematological variables and the level of viraemia were significantly less in the vaccinated group.