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Decreased skin reactivity to codeine in patients with the acquired immunodeficiency syndrome.

par Simonart, Thierry ;Parent, Dominique ;Heenen, Michel ;Farber, Claire ;Van Vooren, Jean-Paul
Référence Clinical immunology and immunopathology, 81, 1, page (12-15)
Publication Publié, 1996-10

Article révisé par les pairs

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Résumé :

To evaluate the skin reactivity and the mast cell releasibility in the acquired immunodeficiency syndrome (AIDS), 24 patients with AIDS were skin tested with histamine (1 mg/ml) and codeine phosphate (0.9, 0.09, and 0.009 mg/ml), a mast cell degranulating agent. They were compared to 12 HIV-negative healthy volunteers and 16 urticaria-prone subjects. Reactivity to codeine phosphate was lower in patients with AIDS than in HIV-negative subjects. This difference in skin reactivity was the more significant when the AIDS group was compared to the urticaria-prone group. There was no correlation between the reactivity to codeine and the IgE levels. Possible explanations to the decreased skin reacting to codeine in patients with AIDS include a decrease of local mast cell density or releasibility. This suggests that a mechanism related to urticaria and involving mast cells is quite unlikely to be at the origin of the hypersensitivity reactions observed in AIDS.