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Multicenter, noncomparative study of caspofungin in combination with other antifungals as salvage therapy in adults with invasive aspergillosis.

par Maertens, J.;Glasmacher, Axel;Herbrecht, R;Thiebaut, Anne;Cordonnier, Catherine;Segal, Brahm H;Killar, John;Taylor, Arlene;Kartsonis, Nicholas;Patterson, Thomas F;Aoun, Michel ;Caillot, Denis;Sable, Carole;Caspofungin Combination Therapy Study Group,
Référence Cancer, 107, 12, page (2888-2897)
Publication Publié, 2006-12

Article révisé par les pairs

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Résumé :

Caspofungin inhibits synthesis of beta-1,3-glucan, an essential component of the Aspergillus cell wall. This echinocandin has demonstrated efficacy (45% success) as salvage monotherapy of invasive aspergillosis (IA). Interest remains as to whether caspofungin, in combination with other antifungal classes, can improve the efficacy against IA.