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Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1-98.

par Coates, Alan;Keshaviah, A;Thürlimann, Beat;Mouridsen, Henning;Mauriac, Louis;Forbes, John F;Paridaens, R. ;Castiglione-Gertsch, Monica;Gelber, Richard;Colleoni, Marco Angelo;Lang, Istvan;Del Mastro, Lucia;Smith, Ian;Chirgwin, Jacquie;Nogaret, Jean-Marie ;Pienkowski, Tadeusz;Wardley, Andrew;Jakobsen, Erik H.;Price, K;Goldhirsch, Aron
Référence Journal of clinical oncology, 25, 5, page (486-492)
Publication Publié, 2007-02

Article révisé par les pairs

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Résumé :

Previous analyses of the Breast International Group (BIG) 1-98 four-arm study compared initial therapy with letrozole or tamoxifen including patients randomly assigned to sequential treatment whose information was censored at the time of therapy change. Because this presentation may unduly reflect early events, the present analysis is limited to patients randomly assigned to the continuous therapy arms and includes protocol-defined updated results.