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Kinetics of induction of error prone repair of bacteriophage λ by temperature shift in an Escherichia coli dnaB mutant

par Caillet Fauquet, Perrine ;Defais, Martine
Référence Molecular & general genetics : MGG, 155, 2, page (231-234)
Publication Publié, 1977

Article révisé par les pairs

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Résumé :

Preincubation at 42 degrees, before infection at permissive temperature by phage lambda, of an Escherichia coli dnaB mutant, provokes a significant increase in survival and mutagenesis of ultraviolet irradiated phage as well as mutagenesis of untreated phage. Similarly to UV irradiation and many chemical mutagens, the inhibition of DNA synthesis by temperature shift of this dnaB mutant induces SOS repair. This work shows that replication blockage in bacterial DNA is not only mutagenic for bacterial DNA itself (Witkin, 1975) but also for normally replicating lambda DNA, probably due to induction of diffusible products.