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Responsiveness of the aging circadian clock to light

par Benloucif, Susan;Green, Kirk;L'Hermite-Balériaux, Mireille ;Weintraub, Sandra;Wolfe, Lisa;Zee, Phyllis
Référence Neurobiology of aging, 27, 12, page (1870-1879)
Publication Publié, 2006-12

Article révisé par les pairs

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Résumé :

The present study assessed whether advances in sleep times and circadian phase in older adults might be due to decreased responsiveness of the aging circadian clock to light. Sixteen young (29.3 ± 5.6 years) and 14 older adults (67.1 ± 7.4 years) were exposed to 4 h of control dim (10 lux) or bright light (3500 lux) during the night. Phase shifts of the melatonin rhythm were assessed from the nights before and after the light exposure. Bright light delayed the melatonin midpoint in both young and older adults (p < 0.001). Phase delays for the older subjects were not significantly different from those of the young subjects for either the bright or dim light conditions. The magnitude of phase delays was correlated with both sleep offset and phase angle in the older, but not the younger subjects. The present results indicate that at light intensities commonly used in research as well as clinical practice older adults are able to phase delay to the same extent as younger subjects. © 2005 Elsevier Inc. All rights reserved.