par Zouaoui Boudjeltia, Karim 
;Moguilevsky, Nicole ;Legssyer, Ilham ;Babar, Sajida ;Guillaume, Michelle ;Delree, Paul;Vanhaeverbeek, Michel ;Brohée, Dany ;Ducobu, Jean ;Remacle, Claude
Référence Biochemical and biophysical research communications, 325, 2, page (434-438)
Publication Publié, 2004-12
;Moguilevsky, Nicole ;Legssyer, Ilham ;Babar, Sajida ;Guillaume, Michelle ;Delree, Paul;Vanhaeverbeek, Michel ;Brohée, Dany ;Ducobu, Jean ;Remacle, ClaudeRéférence Biochemical and biophysical research communications, 325, 2, page (434-438)
Publication Publié, 2004-12
Article révisé par les pairs
| Résumé : | The present paradigm of atherogenesis proposes that low density lipoproteins (LDL) are trapped in subendothelial space of the vascular wall where they are oxidized. Myeloperoxidase (MPO) plays a key role in oxidative damage. We propose that LDL oxidation by myeloperoxidase (Mox-LDL) could occur at the surface of the endothelial cells and not restricted to the subendothelial space. The triad constituted by endothelial cells, circulating LDL and MPO in close interaction, constitutes a synergic mechanism for the genesis of Mox-LDL. © 2004 Elsevier Inc. All rights reserved. |
