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The integration of conventional and unconventional T cells that characterizes cell-mediated responses.

par Pennington, Daniel J;Vermijlen, David ;Wise, Emma L;Clarke, Sarah L;Tigelaar, Robert E;Hayday, A C
Référence Advances in immunology, 87, page (27-59)
Publication Publié, 2005

Article révisé par les pairs

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Résumé :

This review builds on evidence that cell-mediated immune responses to bacteria, viruses, parasites, and tumors are an integration of conventional and unconventional T-cell activities. Whereas conventional T cells provide clonal antigen-specific responses, unconventional T cells profoundly regulate conventional T cells, often suppressing their activities such that immunopathology is limited. By extrapolation, immunopathologies and inflammatory diseases may reflect defects in regulation by unconventional T cells. To explore the function of unconventional T cells, several extensive gene expression analyses have been undertaken. These studies are reviewed in some detail, with emphasis on the mechanisms by which unconventional T cells may exert their regulatory functions. Highlighting the fundamental nature of T-cell integration, we also review emerging data that the development of conventional and unconventional T cells is also highly integrated.