HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient data.

Di Leo, Angelo; Desmedt, Christine; Bartlett, John M S; Piette, Fanny; Ejlertsen, Bent; Pritchard, Kathleen; Larsimont, Denis; Poole, Christopher; Isola, Jorma; Earl, Helena; Mouridsen, Henning; O'Malley, Frances P; Cardoso, Fatima; Tanner, Minna; Munro, Alison; Twelves, Chris J; Sotiriou, Christos; Shepherd, Lois; Cameron, David A; Piccart-Gebhart, Martine; Buyse, Marc; HER2/TOP2A Meta-analysis Study Group

doi:doi/10.1016/S1470-2045(11)70231-5

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Article révisé par les pairs

Résumé :

Prediction of response to anthracycline-based therapy for breast cancer is challenging. We aimed to assess the value of HER2 and TOP2A as predictive markers of response to anthracycline-based adjuvant therapy in patients with early breast cancer.

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