par André, Josette ;Richert, Bertrand
Editeur scientifique Vereecken, Pierre ;Awada, Ahmad
Référence Handbook of skincare in cancer patients, Nova Science, New York
Publication A Paraître, s.d.
Partie d'ouvrage collectif
Résumé : Nail involvement during chemotherapy is common. Because of the kinetic of nail formation, the nail changes appear several weeks after drug intake. They are characterized by the involvement of several nails, rarely all twenty nails, more often on the fingers than on the toes. Clinical presentation depends on the duration and severity of the toxic injury as well as on the nail component involved, and may result in Beau's lines, onychomadesis, longitudinal melanonychia, onycholysis or pyogenic granuloma. The pathogenesis of nail damage is often not fully understood. These side effects disappear upon cessation of the treatment with the offending drug. They however rarely alter the patient's quality of life and do not impose treatment discontinuance, except occasionally when the most recent chemotherapeutic drugs are involved (taxanes and epidermal growth factor receptor (EGFR) inhibitors). Management is very conservative and mostly orientated towards adequate nail care, in order to help the patient overcome these side effects until the chemotherapy is completed. © 2012 by Nova Science Publishers, Inc. All rights reserved.