par Mavroudakis, Nicolas ;Caroyer, Jean-Marc;Brunko, Eric ;Zegers De Beyl, Diederik
Référence Electroencephalography and clinical neurophysiology, 105, 2, page (124-127)
Publication Publié, 1997-04
Article révisé par les pairs
Résumé : We studied the effect of an acute loading dose of vigabatrin on threshold of motor responses and duration of silent period elicited with cortical magnetic stimulation in normal subjects. In contrast to phenytoin, vigabatrin does not increase the motor threshold of first dorsal interosseus muscle. We also show that, although vigabatrin increases GABA concentrations in the central nervous system, duration of silent period studied at various stimulus intensities is not modified after vigabatrin administration.