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Transforming growth factor beta promotes development of fibrosis after repeated courses of acute pancreatitis in mice.

par Van Laethem, Jean-Luc ;Robberecht, Patrick ;Grégoire, Anne ;Devière, Jacques
Référence Gastroenterology, 110, 2, page (576-582)
Publication Publié, 1996-02

Article révisé par les pairs

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Résumé :

Transforming growth factor beta (TGF-beta) is a putative mediator of fibrosis in several chronic diseases. Recently, chronic pancreatitis was suggested to be related to acute pancreatitis in the so-called necrosis-fibrosis sequence hypothesis. The present study investigated whether TGF-beta is able to promote chronic fibrosis after repeated courses of necrotizing acute pancreatitis induced by cerulein in mice.