par Wybran, Joseph 
;Govaerts, André ;Van Dam, D.;Appelboom, Thierry
Référence International journal of immunopharmacology, 1, 2, page (151-155)
Publication Publié, 1979
;Govaerts, André ;Van Dam, D.;Appelboom, Thierry Référence International journal of immunopharmacology, 1, 2, page (151-155)
Publication Publié, 1979
Article révisé par les pairs
| Résumé : | The influence of lynestrenol, a synthetic progesterone-like drug, has been investigated on normal human blood leucocytes in vitro. Lynestrenol significantly increased the percentage of active T rosettes (a test for T-cell competence) at concentrations of 10-1 to 10-4 μg/ml (controls: 16.5%; drug at 10-1 μg/ml; 23.6%; P<0.001). It did not alter the percentage of total T rosettes (a quantitative measure of T cells) and the percentage of EAC rosettes. It increased the non-adherent cells in the leucocyte adherence inhibition test (LAI) over a dose range between 10-1 and 10-3 μg/ml (controls: 360,000 compared to 517,000 in the presence of 10-2 μg/ml; P<0.001) suggesting some leucocyte activation. Finally, it also increased the phagocytic properties of monocytes. These results indicate that lynestrenol acts upon normal human blood T lymphocytes, monocytes and possibly neutrophils. Therefore, lynestrenol appears to possess immunostimulatory properties. |
