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Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents.

par Evdokimov, Nikolai M;Van Slambrouck, Séverine;Heffeter, Petra;Tu, Lee;Le Calve, Benjamin ;Lamoral-Theys, Delphine ;Hooten, Carla J;Uglinskii, Pavel Y;Rogelj, Snezna;Kiss, Robert ;Steelant, Wim F A;Berger, Walter;Yang, Jeremy J;Bologa, Cristian G;Kornienko, Alexander;Magedov, Igor V
Référence Journal of medicinal chemistry, 54, 7, page (2012-2021)
Publication Publié, 2011-04

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Titre:	Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents.
Auteur:	Evdokimov, Nikolai M; Van Slambrouck, Séverine; Heffeter, Petra; Tu, Lee; Le Calve, Benjamin; Lamoral-Theys, Delphine; Hooten, Carla J; Uglinskii, Pavel Y; Rogelj, Snezna; Kiss, Robert; Steelant, Wim F A; Berger, Walter; Yang, Jeremy J; Bologa, Cristian G; Kornienko, Alexander; Magedov, Igor V
Informations sur la publication:	Journal of medicinal chemistry, 54, 7, page (2012-2021)
Statut de publication:	Publié, 2011-04
Sujet CREF:	Sciences bio-médicales et agricoles
MeSH keywords:	Antineoplastic Agents -- chemical synthesis -- chemistry -- pharmacology
	Biological Agents -- chemical synthesis -- chemistry -- pharmacology
	Cell Line, Tumor
	Cell Proliferation -- drug effects
	DNA Topoisomerases, Type I -- metabolism
	DNA Topoisomerases, Type II -- metabolism
	Humans
	Inhibitory Concentration 50
	Topoisomerase II Inhibitors -- chemical synthesis -- chemistry -- pharmacology
	Uracil -- chemical synthesis -- chemistry -- pharmacology
Note générale:	Journal Article
	Research Support, N.I.H., Extramural
	Research Support, Non-U.S. Gov't
	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0022-2623
	info:doi/10.1021/jm1009428
	info:scp/79953775167
	info:pmid/21388138