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The S3a ribosomal protein gene is identical to the Fte-1 (v-fos transformation effector) gene and the TNF-α-induced TU-11 gene, and its transcript level is altered in transformed and tumor cells

par Lecomte, Fabienne;Szpirer, Josiane ;Szpirer, Claude
Référence Gene, 186, 2, page (271-277)
Publication Publié, 1997-02

Article révisé par les pairs

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Résumé :

Previous work on mouse x rat hybrid cells (BS series) led to the assignment of a transformation suppressor locus (Sail) to the rat 5q22-q33 region. This gene is not yet identified. From a non-transformed BS hybrid cell line, we isolated a partial cDNA insert (13T), which detects a transcript more abundant in transformed cells than in their non-transformed homologs. Sequence comparisons led us to conclude that 13T is identical to the coding sequences of the ribosomal protein S3a gene (Rps-3α), of Fte-1 (v-fos transformation effector gene) and of TU-11, a mouse gene induced by TNF-α. Rps3α, Fte-1 and TU-II are thus one and the same gene. Similarity was also found between this gene,and non-mammalian sequences reported to be involved in cell cycling. Like the Rps3α transcript level, the c-Fos transcript level is higher in transformed cells. Rps3α and Fos could thus be effecters of the transformed phenotype.