par Evano, Gwilherm
Référence L'Actualité chimique, 322, page (20-26)
Publication Publié, 2008
Article révisé par les pairs
Résumé : Natural products and total synthesis have long been an inexhaustible source of inspiration, motivation and considerable innovation and lead to an impressive number of applications in numerous and diverse fields going from organic synthesis to drug development. This article describes one contribution to the synthesis of cyclopeptide alkaloids, a huge family of natural products displaying a wide range of biological activities, starting from amino acids as building blocks and using copper(I) catalysis to install the key structural elements. These syntheses raised general synthetic problems which lead to the development of new procedures and synthetic tools such as preparation of nitrogen heterocycles or cascade reactions for the synthesis of biphenyl ethers.