par de Chassey, B;Navratil, V;Tafforeau, Lionel
;Hiet, M S;Aublin-Gex, A;Agaugué, S;Meiffren, G;Pradezynski, F;Faria, B F;Chantier, T;Le Breton, M;Pellet, J;Davoust, N;Mangeot, P E;Chaboud, A;Pénin, François;Jacob, Y;Vidalain, Pierre Olivier;Vidal, M;André, P;Rabourdin-Combe, C;Lotteau, V
Référence Molecular systems biology, 4, page (230)
Publication Publié, 2008

Référence Molecular systems biology, 4, page (230)
Publication Publié, 2008
Article révisé par les pairs
Résumé : | A proteome-wide mapping of interactions between hepatitis C virus (HCV) and human proteins was performed to provide a comprehensive view of the cellular infection. A total of 314 protein-protein interactions between HCV and human proteins was identified by yeast two-hybrid and 170 by literature mining. Integration of this data set into a reconstructed human interactome showed that cellular proteins interacting with HCV are enriched in highly central and interconnected proteins. A global analysis on the basis of functional annotation highlighted the enrichment of cellular pathways targeted by HCV. A network of proteins associated with frequent clinical disorders of chronically infected patients was constructed by connecting the insulin, Jak/STAT and TGFbeta pathways with cellular proteins targeted by HCV. CORE protein appeared as a major perturbator of this network. Focal adhesion was identified as a new function affected by HCV, mainly by NS3 and NS5A proteins. |