Résumé : Background: In low-income countries, illness-related costs incurred by patients constitute a severe economic burden for households. The weak uptake and poor success of the tuberculosis program in Burkina Faso is a major problem for national and international authorities. Objective: To estimate out-of-pocket costs related to tuberculosis (TB) caused by inefficient health-care system Method: In 2008, we conducted 242 in-depth interviews among smear-positive pulmonary tuberculosis cases enrolled in the national tuberculosis program in rural Burkina Faso. We assessed cost burden by collecting data on household income and direct and indirect costs related to tuberculosis. Results: Median direct costs were €69.3 [IQR: 36.4 - 118.1] and corresponded to 2.8 months of household income [IQR: 1.1 - 5.2]. Through a better rationalisation of the demand and supply of healthcare, half of the households could save up to 50% or more of their direct expenses related to TB and could reduce significantly their opportunity cost. Catastrophic health costs that patients have to cope with are largely unjustified and thus potentially avoidable. Conclusion: The cost burden related to tuberculosis in rural Burkina Faso is due mainly to bottlenecks in the health system (i.e.: multiplied encounters to several health-care professionals, etc). To reduce undue tuberculosis-related costs, health-system strengthening mechanisms must focus on improving health services. This is a priority because too many people are still facing catastrophic health expenses.