Titre :
  • A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library.
Auteur : Takacs, Zoltan ; Toups, Megan ; Kollewe, Astrid ; Johnson, Erik ; Cuello, Luis G ; Driessens, Grégory ; Biancalana, Matthew ; Koide, Akiko ; Ponte, Cristiano G ; Perozo, Eduardo ; Gajewski, Thomas F. ; Suarez-Kurtz, Guilherme ; Koide, Shohei ; Goldstein, Steve A N
Informations sur la publication : Proceedings of the National Academy of Sciences of the United States of America, 106, 52, (page 22211-22216)
Statut de publication : Publié, 2009-12
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Amino Acid Sequence
Animals
Cytokines -- biosynthesis
Drug Design
Female
Humans
Kv1.3 Potassium Channel -- antagonists & inhibitors -- genetics
Ligands
Models, Molecular
Molecular Sequence Data
Neurotoxins -- chemistry -- genetics -- pharmacology
Oocytes -- drug effects -- metabolism
Peptide Library
Peptides -- chemistry -- pharmacology
Potassium Channel Blockers -- chemistry -- pharmacology
Protein Engineering
Rats
Recombinant Proteins -- antagonists & inhibitors -- genetics
Scorpion Venoms -- chemistry -- genetics -- pharmacology
T-Lymphocytes -- drug effects -- immunology -- metabolism
Xenopus laevis
Note : In Vitro
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0027-8424 
info:doi/10.1073/pnas.0910123106
info:pii/0910123106
info:pmid/20007782
info:pmcid/PMC2799710