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Atrial natriuretic peptides in canine hypoxic pulmonary vasoconstriction.

par Vachiery, Jean-Luc ;Lejeune, Philippe ;Hallemans, Roger ;Brimioulle, Serge ;Debieve, Marie-France ;Abramow, Maurice ;Naeije, Robert
Référence Cardiovascular Research, 24, 5, page (352-357)
Publication Publié, 1990-05

Article révisé par les pairs

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Résumé :

Study objective – The aim of the study was to investigate whether atrial natriuretic peptides have a physiological role in regulation of the pulmonary circulation.Design – Plasma concentrations of immunoreative atrial natriuretic peptide and guanosine-3',5'-cyclic monophosphate (cGMP) were measured during evaluation of pulmonary vascular tone by multipoint pulmonary arterial pressure-cardiac index (Ppa/Q) relationships.Subjects – Experimental animals were 17 mongrel dogs of either sex, 21-35 kg weight, anaesthetised with pentobarbitone.Measurements and main results – Measurements of Ppa/Q relationships and atrial natriuretic peptide/cGMP were made during hyperoxia (FiO2 0.4) and hypoxia (FiO2 0.1). Hypoxic pulmonary vasoconstriction, defined as hypoxia induced increase in pulmonary artery pressure over the entire range of Q studied from 2-5 litre·min−1·m−2, was elicited in nine dogs (“responders”). In the other eight dogs, hypoxia did not change pulmonary artery pressure over the entire range of Q studied (“non-responders”). At neither the highest nor the lowest Q in hyperoxia did atrial natriuretic peptide and cGMP concentrations differ between these two groups, nor did acute reduction in Q affect the concentrations in either group. At the highest Q, plasma atrial natriuretic peptide increased in hypoxia from 11(SEM 2) to 15(3) pmol·litre−1 in the responders (p<0.05), and from 15(2) to 20(2) pmol·litre−1 in the non-responders (p<0.05). However at the lowest Q, atrial natriuretic peptide was increased in non-responders only, from 17(3) to 23(4) pmol·litre−1 (p<0.05). CGMP did not vary significantly in any experimental condition.Conclusions – Hypoxia slightly increased plasma atrial natriuretic peptides without any relationship with associated pulmonary haemodynamic changes. These data do not support the hypothesis that atrial natriuretic peptides play a physiological role in the regulation of the pulmonary circulation in dogs.